| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and characterization of O-carboxymethyl chitosan using pH sensitive amphotericin B delivery |
| 초록 |
The aim of this study was to increase therapeutic efficiency of antifungal agent and characterize a pH-sensitive particle as a targeted antifungal agent delivery. The amphotericin B (AmB) as antifungal agent is most effective drug in the treatment of fungal infection. However, AmB is insoluble aqueous solution and highly cytotoxic in low concentration, lmiting phamatherapeutic treatment. This is major problem to use AmB for anti fungal agent. Therefor, PEG modified AmB was conjugated to target ligand modified O-carboxymethyl chitosan (OCMCh). The AmB particle showed pH -sensitive response in fungal growth condition and infection region. The AmB/OCMCh particle structure and AmB content of them were detected by FT-IR spectroscopy, 1H-NMR and HPLC. |
| 저자 |
장재영1, 변지예1, 박순정1, 정경원1, 박성철1, 최창용2, 나재운1, 장미경1
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| 소속 |
1순천대, 2다이나믹 |
| 키워드 |
Amphotericin b; O-Carboxylmethyl chitosan; pH sensitive; polymeric drug.
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| E-Mail |
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