| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
(정밀화학) 의학 진단 화학 프로브 및 약물 개발 |
| 제목 |
PET molecular Imaging study via Bioorthogonal F-18 labeling method |
| 초록 |
F-18 labeling reaction of bioactive molecule via click reaction has been widely used to prepare F-18 labeled molecular imaging probes. In particular, bioorthogonal strain-promoted alkyne-azide cycloaddition (SPAAC) reaction has received much attention as an alternative conjugation method for radiolabeling bioactive molecules. In this presentation, I introduce the efficient mesoporous silica nanoparticles (MSNs) based pretargeting PET imaging protocol via the SPAAC reaction using F-18 labeled azide radiotracer in a live-body of tumor-bearing mice. I also introduce an efficient cell-tracking tool using PET system. From consideration of the fact of homing of macrophage to tumor, the tracking of RAW 264.7 cells using PET system in tumor-bearing mice was designed as a model of cell tracking via in vivo F-18 labeling reaction based on the bioorthogonal SPAAC ligation in the macrophage cells loaded by ADIBO-MSNs on tumor region together with 18F-azide in living subject. |
| 저자 |
김동욱 |
| 소속 |
인하대 |
| 키워드 |
molecular imaging; PET; radiopharmaceutical; F-18; radiotracer
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| E-Mail |
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