| 초록 |
The first attempt of living cells coating has been conducted by organic polymers through layer-by-layer methods. To achieve more practical demonstration, coating materials shifted from organic polymers to inorganic materials. The polymers have been used as catalytic templates for biomimetic synthesis of inorganic materials. Furthermore, it was developed a cytocompatible surface-initiated, atom transfer radical polymerization (SI-ATRP) method for grafting polymers from living cells with use of polydopamine priming. Modulation of cell-surface properties and cellular activities was demonstrated, along with post-functionalibility of polymer coats. Considering a plethora of functional and structural variations in synthetic polymers, grafting polymers from (or to) cell surfaces would generate multifunctional cellular hybrids for many biotechnological and biomedical applications, not to mention providing an advanced tool for chemically manipulating the cells. |
