| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
RGD Peptide conjugated Chitosan Nanoparticles as asiRNA Carrier for Antiangiogenesis |
| 초록 |
Integrins are cell surface factor that mediate cell adhesion, but are also important regulators of tumor cell interactions with their Angiogenesis, New vessel growth. Targeted polymeric gene delivery system, LMWSC(Low molecular weight water soluble chitosan)-PEG-RGD (LMPR), was developed by incorporating the αvβ3 integrin-binding RGD peptide (A dimeric RGD peptide), was recently reported to possess high affinity for αvβ3 integrin, into the cationic polymer, We synthesized LMPR and the physicochemical properties investigated by using 1H-NMR, FT-IR, siRNA complex measured Dynamic light scattering and Transmission Electron Microscope (TEM). The cytotoxicity of LMPR also was determined by MTT assay. The LMPR Nanoparticle was investigated to siRNA carrier. |
| 저자 |
홍락준, 손동희, 박준규, 남정표, 김원석, 최창용, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
LMWSC; Anti-angiogenesis; Target delivery; gene; cancer therapy
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| E-Mail |
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