화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2014년 가을 (10/22 ~ 10/24, 대전 DCC)
권호 20권 2호, p.1578
발표분야 생물화공
제목 3T3-L1 Cell Patterning for Screening of Anti-obesity Agents
초록 Overweight and obesity are the fifth leading risk for global deaths. At least 2.8 million adults die each year as a result of being overweight or obese. Therefore, the development of efficient lipid inhibitor for the biological effects of obesity is highly needed. Especially, the discovery of bioactive compounds from food is one of possible ways to control obesity and to prevent or reduce the risks of various obesity-related diseases. In this study, we described a simple and facile method to generate uniform microwells poly(dimethyl siloxane) (PDMS) microstamps through micro-molding for efficient and reliable cell patterning of adipocyte differentiation. And, we demonstrated this platform can be used for the real-time monitoring of cell proliferation and differentiation in live cell-based assays.
저자 김지용1, 노창현2, 이창수1
소속 1충남대, 2한국원자력(연)
키워드 Micropatterning; Anti-obesity agents; Screening
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