| 초록 |
We have studied various polymer and/or inorganic hybrid coatings for cell culture. In this papery, we present the work on fabrication of micro-fluidic chips for the study of an anticancer drug efficiency and toxicity of the drug-encapsulated hydrogel beads placed within a micro-channel of the device. In order to create efficient cell culture environment as well as avoid the direct contact of the hydrogel beads to the cells, we utilized polyelectrolyte multilayer film modifying the surface of the micro-channels. In our previous studies, different behaviors of the cells were shown depending on the hydrophilicity, functional groups, and morphology of the coating surfaces. Based on the results, we applied the anti-fouling, biocompatible coatings for the microfluidic devices to culture cells effectively and tested real time drug efficiency. Our system may have a great potential in cell-based drug screening and some related biomedical applications. |
