| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
[생체재료] 차세대 생체재료: 오가노이드 기술과 조직재생소재 |
| 제목 |
Development of Human Cardiac Organoids for Drug Screening |
| 초록 |
Drug-induced cardiotoxicity has been one of the major concerns that lead to drug withdrawals from markets and early discontinuation of promising drug candidates. Currently, in vitro hERG ion channel assay and in vivo telemetry for QT screening in conscious animals are used as standardized assays for cardiotoxicity. However, there are several limitations for the absence of physiological environment in the hERG assay and the ethical issues and interspecies differences in animal studies. We have developed cardiac organoids using human induced pluripotent stem cells. In addition, we also developed a comprehensive toxicity testing platform based on electrophysiological and image-based analysis for an in vitro alternative to animal testing. The human cardiac organoid-based toxicity testing platform could be more reliable to evaluate proarrhythmic risk than previous non-clinical assays. |
| 저자 |
이향애 |
| 소속 |
안전성평가(연) |
| 키워드 |
Human stem cell; cardiac organoid; drug screening; cardiotoxicity
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| E-Mail |
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