| 초록 |
Recently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy can treat primary tumors and prevent metastasis and recurrence. However, the current cancer immunotherapies have limited clinical benefits because cancer antigens are often not effectively delivered to immune cells. Furthermore, solid tumors evade anti-cancer immunity by forming an immune-suppressive tumor microenvironment. Here, we demonstrate the use of functional nanoparticles in cancer immunotherapy. First, to address the unmet needs in cell-based immunotherapy, multi-functional nanoparticles are developed for NK cell therapeutics. Next, we deal with a new type of nanoparticle adjuvant with non-thermal electrical ablation for effective cancer immunotherapy. Take all together, the cancer immunotherapy based on nanoparticles is anticipated not only to overcome the limitations of existing immunotherapy but also to generate synergistic effects via cooperation between nanoparticles and immune cells. |
