| 초록 |
Alginate is one of the widely used natural materials because it has good solubility in water and biodegradable properties, as well as the excellent non-toxicity when injected into a human body. Injectable hydrogels offer a wide range of attractive benefits, as an easy-to-use medical device for various applications, including drug delivery and tissue engineering. In this study, injectable hydrogels were fabricated by modification of alginate with tyramine and subsequent enzymatic crosslinking reaction. Their gelation, mechanical and degradation properties were systemically investigated by varying the concentration of HRP and H2O2. The modified alginate were analyzed ATR-FTIR, 1H-NMR in order to confirm the introduction of tyramine. Rheological properties were also tested according to adjusting the amount of H2O2, HRP and concentration of modified alginate solutions. Cell viability of the hydrogels was investigated. Further characterization and biomedical application is now in progress. |
