| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
[생체재료] 미래기술을 위한 바이오 소재 혁신 |
| 제목 |
DNA-Based Functional Materials for Applications in Biosensing and Therapeutics |
| 초록 |
DNA-based materials are attracting so much attention since they allow the design and assembly of well-defined structures by DNA hybridization. Of great importance is the functionalization of these DNA materials with non-nucleic acid components, thereby broadening the bioavailability of materials with limited properties entirely composed of nucleic acids. Here, we have shown a few examples of using nucleic acids as generic materials to construct DNA-inorganic hybrid composites. We co-employed surface-functionalized nanoparticles with DNA and enzyme-triggered or enzyme-free signal amplification approaches to amplify sensor responses. We have further developed robust and straightforward strategies that enable facile conjugation or attachment with various biomolecules and nanoparticles. The proposed concepts represent a promising opportunity to create new functional DNA materials that can substantially advance numerous applications of nucleic acids in biomedical research. |
| 저자 |
김은정 |
| 소속 |
인천대 |
| 키워드 |
DNA-based materials; DNA amplification; biosensing; protein delivery
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| E-Mail |
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