| 초록 |
Indole derivatives are useful as biologically active compounds, such as pharmaceuticals, pesticides, and alkaloids, in Pharmacology and Biochemistry. In recent decades, although several methods to synthesize 3-formylindole have been introduced, people have difficulty using hazardous reagents like strong acids and bases, and reaction time is too long. In contrast, this study leads C3-formylation of indole to occur stably and rapidly in batch and micro reactor. To be specific, 3-formylindole is synthesized by using hexamethylenetetramine as a carbonyl source, iodine as a catalyst, DMF and H2O as a solvent. Moreover, the addition of H2O in DMF brings increased yield for a short reaction time, and this experiment could be applied to a micro reactor. Through using the pressure regulator of the micro reactor, it was possible to react stably above the boiling point of H2O. As a result, we obtained 80% yield within 10min with these several parameters. |
