| 초록 |
In this work, the biocompatible polymer poly (styrene-alt-maleic anhydride) (PSMA) which was synthesized and functionalized with furfuryl pendant groups was used as polymeric backbone. Diels-Alder (DA) click reaction under sonication irradiation was applied for direct grafting of functional polymer on single walled carbon nanotubes (SWCNT). The polymer with different PEG chain lengths was characterized by 1 H NMR, FT-IR, TGA and GPC. By using this technique, SWCNT-graft-PSMF had shown the improvement in DOX loading capacity – up to 270%. Furthermore, in the in-vitro drug release profiles, DOX release at pH 7.4 stayed at low rate (16%), whereas at pH 5.5 there was a burst release of DOX (61%). This evidence indicated the effective pH responsive characteristic of SWCNT-g-PSMF in target release of DOX. Key words: single walled carbon nanotubes, Diels-Alder reaction, pH responsive, poly (styrene-alt-maleic anhydride). |
