| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Injectable Hydrogel Poly(styrene-alt-maleic anhydride)-Based for Controlled Drug Delivery |
| 초록 |
A novel new fast gelling hydrogel composed of copolymer Poly(styrene-alt-maleic anhydride) (PSMA) and poly(ethylene glycol) (PEG) with Inverse Electron Demand Deis-Alder (IEDDA) click reaction between tetrazines and norbornenes. The PSMA were subsequently functionalized with 3-(p-benzylamino)-1.2.4.5-tetrazine. The tetrazine groups, were reacted with dinorbonene chain-end functional polyethylene glycol as a cross-linking agent with IEDDA click reaction to produce a hydrogel. All the precursor materials were characterized by FT-IR, GPC, and 1H-NMR. The resulting hydrogel formation within several minutes and the storage modulus (G’) value of hydrogels was in range 0.3-1.7 kPa. The precursors exhibited practically no depressing effect on the normal HEK293 cell growth while the DOX·HCl-loaded hydrogel presented significant anticancer activity towards HeLa cells, which makes this biocompatible hydrogel potential for controlled drug release. |
| 저자 |
임권택, Daru Seto Bagus Anugrah, K. Ramesh, 박찬, 최원태
|
| 소속 |
부경대 |
| 키워드 |
Injectable Hydrogel; Poly(styrene-alt-maleic anhydride); Click Reaction
|
| E-Mail |
|
