| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 |
20권 2호, p.2414 |
| 발표분야 |
영어심포지엄(주제미정)(분리기술부문위원회 주제별 심포지엄) |
| 제목 |
Use of Crystallization to the Production of Enantiomerically Pure Amino Acids and Labile Antibiotics |
| 초록 |
We describe how crystallization can be combined with chemical reactions in the manufacture of two different types of products. In the first, an enantiomerically pure product is recovered after enriching an initially racemic mixture by chemo-enzymatic stereoinversion. The concept is demonstrated by recovery of an enantiomerically pure amino acid from a solution initially containing a racemic mixture. In the second category, we use crystallization to recover a species that is unstable in the reaction medium used in its synthesis. We use this principle in devising a scheme for enhancing the yield of ampicillin, a beta-lactam antibiotic. During its synthesis, the desired product is subject to hydrolysis, but we show how product loss can be reduced significantly by running the synthesis reaction at conditions where ampicillin is crystallized as it is produced. |
| 저자 |
Ronald W. Rousseau, Luis Encarnacion-Gomez, Andreas Bommarius
|
| 소속 |
Georgia Institute of Technology |
| 키워드 |
crystallization; enantiomeric purity; amino acids; ampicillin; stereoinversion
|
| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
