| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.2693 |
| 발표분야 | SMB 공정개발과 응용 |
| 제목 | Strategies for Improving the Performance of Simulated Moving Bed Chromatography |
| 초록 | Simulated moving bed (SMB) chromatography has received considerable attention because it was a continuous and effective separation process for valuable materials such as enantiomers. For the pharmaceutical industry, extremely high purity is required to achieve the goal of developing safer and more effective drugs. Often, one enantiomer of a racemic mixture demonstrated side-effects or toxicity. In this study, a new “partial-discard” operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. The “partial-discard” concept was also applied to the “partial-feed” operation to enhance the purity as a combined “partial-feed with partial-discard” operation. The results were compared to the conventional “total-feed and total-product” operation approach in consideration of purity, enrichment, and recovery. The results will provide a valuable engineering strategy to improve the performance of the SMB chromatographic process. |
| 저자 | 배윤상, 이창하 |
| 소속 | 연세대 |
| 키워드 | Simulated Moving Bed (SMB) Chromatography; Enantiomer Separation; Performance; Purity |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
