| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Macrophage-mediated conditioned media delivered by alginate patch enhances skin wound healing |
| 초록 |
Wound healing is a complex process involving cells, the extracellular matrix (ECM), cytokines and the interactions between them. Macrophage has roles in the inflammatory and remodeling phase of wound healing, secreting cytokines crucial to angiogenesis, cell migration and ECM remodeling. THP-1 seeded on TCP or human fibroblast derived matrix (hFDM) was subjected to differentiation into different macrophage phenotypes and showed an increased level of CCL1, CCL5, and G-CSF in the conditioned media (CM). Further analysis of collagen synthesis and in vitro scratch test using human dermal fibroblast (hDFB) exhibited more collagen deposition and faster wound closure when treated with M2 macrophage-CM. A concentrated form of the CM was applied to a murine full-thickness skin wound using alginate patch. The results showed faster wound closure and elevated mature collagen distribution. Our study demonstrated the potential of macrophages derived CM as a source of enhanced wound healing. |
| 저자 |
시닌타1, Jae Won Kwon2, Valeyria Drobysheva3, Sang Su Ha4, 박귀덕5
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| 소속 |
1한국과학기술(연), 21Center for Biomaterials, 3Korea Institute of Science and Technology (KIST), 4Center for Biomaterials, 5Korea Institute of Science and Technology |
| 키워드 |
Extracellular matrix; Macrophage; Conditioned media; Wound healing; Alginate patch
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| E-Mail |
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