| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect ofSIS Content on Attachment and Proliferation of Schwann Cell and Olfactory Ensheathing Cell on PLGA/SIS Film |
| 초록 |
Poly(lactic-co-glycolic acid)(PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. Porcine small intestine submucosa(SIS) is accellular tissue and widely used as a biomaterials without immunorejection responses. In this study, we fabricated natural/synthetic biomaterial hybrid films using 0, 10, 20, 40 and 80 % of SIS. Schwann cells(SCs) and olfactory ensheathing cells(OECs) were seeded on PLGA/SIS film and confirmed the effects of adhesion and proliferation on SCs and OECs according to content of SIS. These results suggest that SIS, provide suitable surface to neural cells and proper content affect on culture condition to improve cell adhesion and proliferation. In addition, these information would contribute to design of 3-dimentional PLGA/SIS scaffold for tissue engineered spinal cord regeneration. This work was supported by SCRC (SC4110). |
| 저자 |
김초민, 송이슬, 조은혜, 김순희, 이동원, 유일수, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
small intestinal submucosa; schwann cell; olfactory ensheathing cell; spinal cord regeneration
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| E-Mail |
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