| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Oxygen-releasing macroporous cryogels as a hemostatic wound dressing for wound management |
| 초록 |
Cryogels have been widely applied to tissue regeneration and wound management due to their unique interconnected macroporous structure and high absorption ability. It has been demonstrated that hyperoxia plays a critical role in entire wound healing. Herein, we present O2-releasing macroporous matrices composed of thiolated gelatin and calcium peroxide (CaO2) for improving wound healing. The cryogels are prepared by a CaO2-mediated cross-linking reaction followed by lyophilization. Our cryogels show controllable O2 release behavior by varying CaO2 concentrations and retain hyperoxia levels for up to 14 hours in vitro. We demonstrate biocompatible cryogels enhance wound closure and vascular recruitment by released O2 and high porosity of cryogels. Our cryogels also show hemostatic capacity due to the synergetic effect of high absorption ability and released calcium ions. In sum, O2-releasing cryogels have great potential as ideal wound dressing materials for facilitating wound healing. |
| 저자 |
김솔, 박경민
|
| 소속 |
인천대 |
| 키워드 |
Polymeric cryogels; oxygen; wound healing
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| E-Mail |
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