| 초록 |
To date, polymer micelles mineralized with natural inorganic species, such as calcium phosphate (CaP) or calcium carbonate, have been utilized as smart nanocarriers for cancer therapy. In this work, we describe a CaP-mineralized polymer micelle that can protect the drug release in blood and trigger the facilitated release at endosomal pH. It is known that CaP is naturally found as the main mineral component in bone. We selected doxorubicin (DOX) as an anticancer drug, and the DOX-loaded polymer micelles (DOX-PMs) were prepared by self-assembly of poly(ethylene glycol)-b-poly(L-3,4-dihydroxyphenylalanine) copolymer in the presence of DOX. For mineralization of DOX-PMs, the calcium cations and phosphate anions were sequentially added to the aqueous solution of DOX-PMs. The DOX-loaded mineralized polymer micelles described in this work may serve as a robust nanocarrier for cancer chemotherapy. |
