| 초록 |
Folic acid-conjugated SiO2/TiO2 hollow nanoparticles (FA–HNP, ca. 50 nm in diameter) are employed to encapsulate protoporphyrin (PpIX). The FA–HNP–PpIX is used as a photodynamic therapy (PDT) for cancer. It has excellent mono-dispersity and a high loading efficiency for PpIX, and can generate singlet oxygen atoms under visible light excitation. Two human breast cancer cell lines, namely MCF-7 (folate receptor positive; FR+) and SK-BR-3 (folate receptor negative; FR-), are used as targeting and controlling cell lines, respectively. When MCF-7 cells are treated with FA–HNP–PpIX and irradiated, the viability decreased to 25.5%, which is 3.33 times higher PDT efficiency than previous PpIX-based systems. The FA–HNP–PpIX system offers a new opportunity to facilitate implementation of a hydrophobic photosensitizer for effective PDT treatment of tumor cells having the folate receptor (FR). |
