| 초록 |
In this study, super-paramagnetic iron oxide nanoparticles (IONs) were synthesized by the thermal decomposition method. For chemotherapy and negative magnetic resonance imaging contrast agents applications, the IONs were coated with polyaspartamide (PA) to enhance their biocompatibility and hydrophilicity (PA-coated IONs). Polysuccinimide (PSI) is the backbone of polyaspartamide, which is biocompatible, biodegradable. Multifunctional polymers were grafted on PSI, including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) for amphiphilic structure, biotin to interact with its receptors on cancer cell surfaces. And hydrazine hydrate, a pH-sensitive group, was also grafted to PSI to carry and release antitumor drugs such as Doxorubicin in tumor pH environments. The structure and biomedical properties of PA-coated IONs were investigated in vitro and in vivo experiments. |
