| 초록 |
Tissue adhesives have been widely used for biomedical applications. Despite great progress on the study of bioadhesives, it is still challenging to develop advanced adhesives with bioactive properties. Molecular oxygen (O2) is crucial as a biological signaling molecule in the wound healing process. Herein, we develop a new type of O2-generating hydrogel formed via disulfide bonds and in situ dopamine (DA) polymerization in calcium peroxide (CaO2, CP)-mediated crosslinking. The oxidation of DA was accelerated by CP mediated-O2 supply, resulting in rapid polydopamine formation within the matrices. The hydrogels generate O2 up to 70% pO2 and maintain hyperoxic condition for 7 days. The hydrogels show controllable tissue adhesiveness (15 − 38 kPa). We demonstrate that the bioactive adhesives facilitate wound closing rate and remodeling with enhanced neovascularization. Taken together, we suggest that our O2-generating bioadhesive holds great potential for advanced wound management. |
