| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of conjugated Fatty acid modified O-Carboxymethyl Chitosan Nanoparticles |
| 초록 |
The objective of the present study was to develop a new drug carrier consisting of particles utilized O-Carboxylmethyl chitosan (OCMCh) with fatty acid (Fa). A primary amine of OCMCh was modified with Fa for preparation OCM-Fa that induced hydrophobic moiety to NH2 position of OCMCh. The particles form self-aggregates in an aqueous phase by hydrophobic interaction between hydrophobic Fa attached to OCMCh with hydrophobic drug. We have found that OCM-Fa can deliver poorly water soluble drug. OCM-Fa was characterized in terms of FT-IR, 1H NMR, DLS, TEM, stability and drug release. This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MEST) (2012-014898). |
| 저자 |
김태훈, 김기호, 김대한, 오현진, 최창용, 박영훈, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
Antibiotic; O-Carboxylmethyl chitosan; fatty acid
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| E-Mail |
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