| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.174 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Solid Dosage Form containing SMEDDS of Simvastatin by Microencapsulation |
| 초록 | In this study, the release pattern and loading efficiency of simbastatin were examined by cationic lipid ratio. Solidified-emulsion containing a drug substance was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (hydroxypropyl methylcellulose, starch, etc.). The mixtures were dropped into the aqueous solution containing calcium chloride as crosslinker. Obtained solidified-emulsion was washed with the distilled water to remove the unreacted calcium chloride and the washed solidified-emulsion beads were freeze-dried for 48hrs. The containing emulsion, product readily redispersed in proper media without re-aggregation because of containing prepared emulsion by self-emulsifying system. Oil droplet size of redispersed solidified-emulsion in media was reconstituted the smaller droplet size than the initial size. The drug content of beads increased with increasing cationic lipid content, alginate content and the washing time at constant other contents. The release pattern of simvastatin was also investigated in gastric and intestinal fluids to evaluate the effect of pH in in vitro dissolution. This system had advantages easily storage and predictability of drug release rate and may be useful as an oral administration dosage form. Acknowledgement : This work was supported by KMOCIE |
| 저자 | 강복기;서광수;길희주;정상영;강길선;조선행;이해방 |
| 소속 | 전북대 |
| 키워드 | simbastatin; SMEDDS; oral administration dosage form; solidified-emulsion |
