| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hybrid of baculovirus and galactosylated PEI for efficient gene carrier |
| 초록 |
Baculovirus, containing an appropriate eukaryotic promoter, is considered an attractive approach for an efficient and safe gene delivery vehicle. To overcome the drawbacks including non-specific and inactivation by complement system, however, a hybrid system utilized for combining the positive aspects of both viral and non-viral vector systems. In this study, we constructed a hybrid system composed of baculovirus and galactosylated polyethylenimine (GP) as the viral and non-viral vector component, respectively. The resulting GP/B hybrid had suitable physicochemical properties and low cytotoxicity for use in gene therapy. Furthermore, the GP/B significantly enhanced transfection efficiency and showed good cell-specificity compared to either viral or non-viral vector systems. These results suggest that the GP/B hybrid system can be used in gene therapy to enhance transfection efficiency and hepatocyte specificity. |
| 저자 |
김유경, 최재영, 강호림, 로히다스, 다난자이, 조명행, 제연호, 조종수
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| 소속 |
서울대 |
| 키워드 |
gene therapy; targeted delivery; hybrid system; baculovirus; galactosylated PEI
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| E-Mail |
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