| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
In Vivo Real-Time Monitoring of Hyaluronic Acid Derivative As A Novel Drug Carrier Using Quantum Dots |
| 초록 |
Pharmacokinetic analysis of hyaluronic acid (HA) derivative as a novel drug carrier was carried out by the real-time bio-imaging using quantum dot (QDot). HA-ADH with ADH content of ca. 70 mol% was synthesized and conjugated with QDot containing carboxyl terminal ligands which were activated by the addition of sulfo-NHS and EDC in water. The resulting HA-QDot conjugates were injected to nude mice subcutaneously. The photoluminescence of HA-QDot conjugate with time well corresponded to the plasma concentration profile of FITC labeled HA. The results successfully demonstrated in vivo real-time monitoring of the absorption of HA derivatives to nude mice. |
| 저자 |
김지석, 한세광
|
| 소속 |
포항공대 |
| 키워드 |
hyaluronic acid; quantum dot; phramacokinetics
|
| E-Mail |
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