| 학회 | 한국재료학회 |
| 학술대회 | 2014년 봄 (05/15 ~ 05/16, 창원컨벤션센터) |
| 권호 | 20권 1호 |
| 발표분야 | 제26회 신소재 심포지엄-Recent development of catecholamine-based materials and technology |
| 제목 | Mussel-inspired biological surface modification toward bioactive materials |
| 초록 | Surface properties are of prime importance in establishing the response to tissue from biomaterials. We have investigated the immobilization of growth factor proteins to provide a set of very powerful signals for cells. Immobilized growth factors stimulated cultured cells for a longer time and enhanced cell growth more than did soluble growth factors and also induced cellular differentiation. In addition, the effects of immobilized growth factors were visualized by micropatterning them on substrates. However, in order to expand the utilization of immobilized growth factors, it is important to immobilize various materials including inorganic materials. To modify the various surfaces, binding motifs of underwater adhesive proteins containing non-canonical amino acids such as phosphorylated serine from salivary statherin and 3,4-dihydroxyphenylalanine (DOPA) from mussel protein are worth considering. We used DOPA or the derivative dopamine to modify the surface and to immobilize growth factors. One is immobilization of growth factors on the “polydopamine”-formed metal surfaces, another is DOPA incorporation into growth factors for binding affinity to organic and inorganic materials. We compared the biomimetic modification methods. |
| 저자 | Yoshihiro Ito |
| 소속 | Nano Medical Engineering Laboratory |
| 키워드 | polydopamine; surface modification; growth factor; biomaterials |
