| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Comparison of inflammatory response in drug-eluting stents coated with various biodegradable polymers |
| 초록 |
Biodegradable polymers have been used to develop cardiovascular prostheses such as vascular grafts and stents. However, thrombosis, inflammation, and restenosis that are associated with implant are still major obstacles for the use of these devices. The lack of endothelial cell (EC) lining (endothelialization) and the response of immune systems to the stents have been associated with these complications. In addition, several clinical studies have focused on the early markers or initiators of the inflammatory response in coronary stenting. The clinical reports demonstrated that some inflammatory markers, C-reactive protein (CRP), IL-6, and IL-1 exhibited relative rise in the first 10 minutes after inserting stent. We have examined the expression levels of IL-6 after treating smooth muscle cell (SMC) and EC with the degradation product of various polymers and sirolimus (SRL). |
| 저자 |
서성호1, 정윤기1, 최지연1, 김익환2, 한동근1
|
| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
inflammation; drug-eluting stent; biodegradable polymers; endothelial cell; smooth muscle cell
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| E-Mail |
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