| 초록 |
Adhesives and coatings from marine invertebrates have been investigated as a source of potential biomedical underwater adhesives. These properties include strong adhesion to various material substrates, water displacement, biocompatibility, and controlled biodegradability. The mystery of underwater adhesive and coating materials exploited by marine invertebrates is hidden in the complex coacervate phenomena and L-3,4-dihydroxyphenyl alanine(DOPA) chemistry. Complex coacervation in marine adhesives as liquids that readily spread over the target, wet surfaces, fills gaps and does not disperse into the seawater. DOPA plays two role: interfacial adhesion of the coacervate phase and cohesive cross-linking of the dense coacervate phase. Here, we coacervated hyaluronic acid(HA) and recombinant mussel adhesive protein with the RGD peptide(fp-151-RGD) and exploited the low interfacial energy of the coacervate to coat titanium(Ti), a metal widely used in implant materials. |
