| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Robust Crosslinked Hyaluronic Acid Nanoparticles with High Biostability and Tumor targetability as Drug Carrier for Cancer Therapy |
| 초록 |
Self-assembled polymeric nanoparticles have emerged as promising carrier for the delivery of imaging and therapeutic agents. As these polymeric nanoparticles are in the physically self-assembled state, they suffer from poor structural integrity under in vivo conditions due to large dilution after intravenous injection. Therefore, considerable amount of drugs may be released before reaching their target site. In this study, we prepared the hyaluronic acid (HA)-based nanoparticles with the improved stability through a facile crosslinking method. The physicochemical characteristics the HA nanoparticles were investigated in detail using FT-IR, 1HNMR, DLS and UV-Visible spectroscopy. |
| 저자 |
한화승, Gurusamy Saravanakumar, 엄우람, 이은숙, 변재현, 박재형
|
| 소속 |
성균관대 |
| 키워드 |
Hyaluronic Acid; Crosslinked Nanoparticles; Drug carrier
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| E-Mail |
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