| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 가을 (11/02 ~ 11/04, 경원대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Preparation and In vitro test of Cancer targeted Polymericdrug |
| 초록 |
Paclitaxel, an anticancer agent extracted from the bark of the Pacific yew (Taxus brevifolia), has demonstratedsignificant activity in clinical trials against a variety of tumors one of the major clinical problems of using paclitaxel is its very low solubility in water, due to its extremely hydrophobic nature. The Transferrin-PEG-Paclitaxel(TFPXPEG)weresynthesized by coupling reaction of PEG-Paclitaxel (PXPEG) and Transferrin for Target Moiety drug delivery system. The structure was investigated by Fourier transform infrared, and ¹H Nuclear magnetic resonance, Solubillity measurement by Ultraviolet visible, Particle formation was confirmed byTransmission electron microscopy, Electrophoretic LS spectrophotometer.TFPXPEG maintain the pharmacologicalactivity of paclitaxel and efficiently deliver it to the cells.The TFPXPEGhave excellentpotential as apolymeric drug carrier of cancer therapy agent. |
| 저자 |
손동희, 남정표, 박준규, 김원석, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
polymericdrug; transferrine; PEG; paclitaxel
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| E-Mail |
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