| 초록 |
Variety of therapeutic proteins were developed and efficient delivery carriers are required for its successful therapeutic outcome. In this study, biocompatible and biodegradable suture was developed as a vehicle for delivery of adeno associated virus. The developed suture was comprised of fibers formed by polyelectrolyte complexation of chitosan and heparin, and adeno-associated virus were immobilized during the fiber spinning process. Adeno-associated virus were immobilized onto the suture and their activities were retained, successfully transfecting cells seeded on the suture. Also, the In vivo GFP expression through the suture was confirmed. It is concluded that localized gene delivery of adeno-associated virus for gene therapy can be achieved with biocompatible suture which composed to chitosan and heparin interfacial polyelectrolyte complexed fiber and thereby demonstrate the potential for medical device that could also function as gene delivery platforms |
