| 초록 |
In this study, the hydrophilic diblock copolymer (HDC)was synthesized as the coating material on the superparamagnetic iron oxide nanoparticles (SPION). The block copolymer was designed to have an ability to specifically binds to activated macrophages of the atherosclerotic plaque. The HDC was readily coated on the SPION in an aqueous environment. The resulting nanoparticles were characterized using dynamic light scattering, transmission emission microscopy, and FT-IR. From the in vitro study using the RAW264.7 macrophage cell, it was found that the coated nanoparticles showed enhanced cellular uptake, compared to the conventional dextran-coated SPION. The results suggested that the coated SPION has a potential as the MR imaging agent for atherosclerosis. |
