| 초록 |
Plastics production has been dramatically increased due to their strong adbantages it offers. Used plastics are discarded in ocean, randomly breakdown by external stress without chemical decomposition. The microplastics which size is less than 5 mm is emerging as a signifcant threat to marine biota, resulting in hazard to human being. In this study, we have demonstrated the human toxicology of commonly used plastics; polyethylene (PE) and polypropylene (PP) microdebris. The morphology of randomly broken microplastics by milling were statistically analyzed, measuring correlation with morphology and physical properties of each plastic. Furthermore, we have analyzed overall toxicity such as viability, immune response, hemolysis, ROS production using human-derived cells including immune cells, cancer cells, and adult cells. We observed that the PE showed slighy cytotoxic effects as their physical sharpness, on the other hand, PS showed severe cytotixicty due to chemical/physical effects. |
