| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.328 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Development of microbead-based scaffold for vascular grafts |
| 초록 | Development of biodegradable scaffold for a controllable tissue engineering of vascular grafts has been one of the most interesting research topics because of its scientific and industrial importances. Controllable tissue engineering may be obtained by designing the interactions of cells and their ligands via probably either delivery of bioactive drugs for specific tissue regeneration or immobilization of cellular specific ligands on the scaffold surfaces. We have developed a hybrid biodegradable scaffold containing a microbead with bioactive molecules for a control of tissue regeneration. The main biodegradable polymers and the bioactive molecules were polylactide derivatives and cell adhesion molecules, respectively. The bioactive molecules were deposited in a microbead which was synthesized by a conventional o/w/o method. The scaffolds for a vascular application were fabricated as tube types with a 3 to 5 mm inside diameter and a 500 micrometer wall thickness. While the microbeads deposited in the scaffold nodes were observed by SEM, the bioactive molecules by counting the radio-labelled heparins as model molecules. More than 90% of scaffold porosity was obtained from the judgement of porosimetry measurement. Cellular interactions of these bioactive molecules containing scaffolds are currently tested by employing vascular cells such as endothelial cells and smooth muscle cells for the verifications of the biological effects of the bioactive molecules deposited in the scaffolds. |
| 저자 | 정성광, 권순미, 최윤정, 강은주, 노인섭 |
| 소속 | 서울산업대 |
| 키워드 | bioactive molecules; biodegradable scafold; tissue engineering; vascular graft |
