| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Thrombin Activatable CT/NIRF Dual Imaging Probe Based on Gold Nanoparticles |
| 초록 |
Gold nanoparticles (AuNPs) are a unique material because of their controllable morphology, low cytotoxicity, surface plasma resonance effect and high X-ray absorption. For these reasons, AuNPs have attracted scientist’s attention that developed AuNPs as an imaging probe. In this study, we developed thrombin activatable CT/NIRF imaging probe which can detect thrombosis in the blood stream. The particles were coated with silica layer to have stability and biocompatibility in human body. Then thrombin activatable peptide conjugated dye (Thr-dye) was conjugated to the nanoparticle surface. For its high X-ray absorption AuNP can be used as CT contrast agent and NIRF dye for fluorescent imaging. |
| 저자 |
권성필1, 김정연2, 김동억3, 권익찬2, 김광명4, 안철희1
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| 소속 |
1서울대, 2한국과학기술(연), 3동국대, 4한국과학기술연구워 |
| 키워드 |
gold nanoparticle; dual imaging; CT; NIRF; thrombin; activatable
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| E-Mail |
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