| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 |
29권 2호, p.671 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Loading and its Release Behavior of PEG-PCL Nanoparticles |
| 초록 |
The self-aggregation behavior and microscopic characteristics of the PEG-b-PCL copolymer self-aggregates, prepared by solvent evaporation method, were investigated by 1H NMR, dynamic light scattering (DLS), and fluorescence spectroscopy. The PEG-PCL block copolymer formed nano-sized self-aggregates in an aqueous environment by intra- and/or intermolecular association between hydrophobic PCL chains. Then, drug loading and its release behavior of clonazepam loaded PEG-b-PCL nanoparticles were investigated. The result revealed that hydrophobic-hydrophilic balances played a crucial role for drug loading and its release behaviors. |
| 저자 |
김태형, 채수영, 최창용, 김동곤, 김명렬, 나재운
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| 소속 |
순천대 |
| 키워드 |
PEG-b-PCL copolymer; nanoparticle; clonazepam.
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| E-Mail |
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