| 초록 |
Core-shell structured PLA nanofiber with highly porosity was fabricated by coaxial electrospinning of PLA and porogen mixtures. Diblock polymer composed of PEG and PLA, which can from reverse micelle in DCM with the presence of water, was synthesized by ring-opening polymerization of d,l-lactide and methoxy PEG, and the pores along the fiber can be prepared by dissolving reverse micelles in MeOH. Because of its core-shell structure, this nanofiber has larger specific area than the traditional ones, making it feasible for higher drug payload. Controlled release can be realized by the degradation of PLA membrane. Fiber was immersed in DCM/MeOH mixture, after drying out, the pores can be covered by a thin PDLLA membrane. PLA is biodegradable, so the pores will appear again after degradation, and drugs can be released through the pores. The degradation time can be controlled by the thickness of the membrane, which can also be controlled by adjusting the immersing time of fiber in DCM/MeOH. |
