| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
The structural stability and biocompatibility of 3D gelatin scaffolds by cross-linking method |
| 초록 |
Bioinks used in 3D bioprinting should have good biocompatibility and printability. Biocompatible and biodegradable gelatin is a good candidate bioink, but printability is poor due to low viscous of gelatin solution. In this study, we improved the printability of the gelatin by controlling the viscous of the gelatin solution. The 3D printed scaffolds were cross-linked using two types of different cross-linking methods (physical and chemical method). The structural stability of cross-linked 3D scaffolds was confirmed by SEM. The sizes of the chemical cross-linked 3D scaffolds were significantly reduced, but the physical cross-linked 3D scaffolds maintained their sizes (less than a 3% reduction). To evaluate the cell proliferation of the 3D scaffold, human dermal fibroblasts cultured on the 3D scaffold. After 14 days of culture, DNA assay showed that the cell proliferation rate of the physical cross-linked 3D scaffold was 44% higher than that of the chemical cross-linked 3D scaffold. |
| 저자 |
최동진1, 이보미1, 박상준1, 정석2, 김천호1
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| 소속 |
1한국원자력의학원, 2고려대 |
| 키워드 |
Bioprinting; gelatin hydrogel; cross-linking; tissue engineering
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| E-Mail |
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