| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Polymeric micelle with iron oxide nanoparicles for anticancer agent |
| 초록 |
The poly(aspartic acid-co-hexadecylamine) (PASP -C16)-coated iron oxide nanoparticles stabilized with poloxamer (F-127) was produced and characterized as a drug carrier system for anticancer agents. Anticancer agents were loaded into the side chain, C16, of PASP backbone surrounding iron oxide nanoparticles prepared by coprecipitaion method and the F-127 that anchors at the C16-water interface conferred aqueous dispersity to the formulation. Doxorubicin base was used as a model anticancer agent on modification of Doxorubicin hydrochloride. The results show that the (PASP-C16)-coated iron oxide nanoparticles stabilized with F-127 nanoparticles can be used as a drug carrier system while simultaneously allowing magnetic targeting and imaging. |
| 저자 |
최혜정1, 서희1, 공광훈2, 육순홍1, 신병철1, 조선행1
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| 소속 |
1한국화학(연), 2중앙대 |
| 키워드 |
Iron oxide nanoparticle; Doxorubicin; Polymeric micelle
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| E-Mail |
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