| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Injectable Formulation Based on Hyaluronic Acid and PEG-TRAIL as a Potential Therapeutics for Arthritis and Cancer |
| 초록 |
Tumor Necrosis Factor related Apoptosis Inducing Ligand(TRAIL) is known to exhibit antitumor and antiinflammatory effects. PEG-TRAIL is a derivative of TRAIL that has similar bioactivity, increased stability, and improved pharmacokinetic profiles. An injectable hyaluronic acid (HA) based PEG-TRAIL formulation was developed for sustained release of PEG-TRAIL while maintaining its stability. PEG-TRAIL/HA hydrogel formulation was prepared by adding HA powder to PEG-TRAIL/HA complex solution. To confirm formation of the PEG-TRAIL/HA complex, the particle size and zeta potential were measured using the dynamic light scattering and the zetasizer. Bioactivity of PEG-TRAIL/HA complex was evaluated in HeLa cell line in vitro. Release of PEG-TRAIL from the formulation was observed by the molecular imaging technique after subcutaneous injection into the mice. This study about PEG-TRAIL/HA formulation might be good approach to treat a cancer or autoimmune diseases. |
| 저자 |
나성주1, 이슬기2, 채수영3, 김광명2, 박재형1, 권익찬2, 정서영1, 이강춘3
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| 소속 |
1경희대, 2한국과학기술(연), 3성균관대 |
| 키워드 |
PEG-TRAIL; HA; hydrogel; formulation. sustained release
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| E-Mail |
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