| 초록 |
Photo-thermal therapy is a highly effective and minimal invasive therapeutic approach for the treatment of cancer. Indocyanine green (ICG), whose light absorption lies on a biological transparent near-infrared region, is widely used as a photo-thermal therapeutic agent in medical diagnostics. However, there is a manifest obstacle in applying ICG for that purpose; that is, its affinity toward proteins (e.g., albumin and lipoprotein), which leads to inevitable loss of dose onto the non-target regions during the treatment. We designed micellar nanoparticles that incorporate metal-ICG complexes. The formulated nanocomposite was able to retain its structural integrity under physiological circumstances, and its fluorescence, a competitive photophysical pathway for transduction of absorbed energy other than heat generation, was almost quenched. It was indeed found that the photo-thermal effect of the nanoparticles is more enhanced in comparison to that of aqueous solution counterpart. |
