| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Inhibition of metastatic skin cancer through nano-micelle generating dissolvable microneedles including doxorubicin |
| 초록 |
Microneedle (MN) has been desired as a therapeutic device which allow cutaneous administration of various drugs with easily and painlessly. Herein, nano-micelle generating dissolvable MN was designed by a biocompatible amphiphilic tri-block copolymer. When fabricating with doxorubicin (DOX) in the MN, the hydrophobic anti-cancer drug can be dissolved in an aqueous medium by encapsulated in nano-micelles generated by dissolution of the MN. The intratumoral administration of the DOX-encapsulated MN can significantly inhibit the growth of melanoma in a mouse skin cancer model. Furthermore, owing to its small size (＜ 50 nm), the nano-micelle can efficiently migrate to the sentinel lymph nodes, killing the metastatic skin cancer cells. Therefore, the use of locally application of MN can be considered as a promising therapeutic device for the inhibition of metastatic melanoma. |
| 저자 |
임수연, 김다훤, 황위보, LYUSIYAN, 김병덕, 박채은, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Microneedle; Dissolvable microneedle; Skin cancer; Metastatic Melanoma; Chemotherapy drug; Doxorubicin
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| E-Mail |
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