| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.379 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Development of oral self-microemulsion dosage form for the rapidly reduced inflammation |
| 초록 | The main purpose of this work is to prepare of self-microemulsifying drug delivery system (SMEDDS) for rapidly oral absorption of a poorly water soluble drug such as dexibuprofen. it is non-steroidal anti-inflammatory(NSAID), analgesic (pain relieving), and antipyretic (fever reducing) drug. SMEDDS are mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using oils, two surfactants, and four cosurfactant and antioxidant (Tocopherol acetate) and pH adjustment agent. The efficiency of emulsification was studied to dissolution test by KP methods type 2 and to determine particle size distributions of the resultant emulsions by a laser diffraction sizer. the result, SMEDDS system containing dexibuprofen was formulated to well stable nanopartcle emulsion into the water. SMEDDS might be a promising approach for the rapid-onset and the absorption into oral administration delivery of dexibuprofen, and could be a rapidly pain relieving and stability for the other poorly water soluble drug. Acknowledgement: This work was supported by KMOCIE |
| 저자 | 강복기1, 전세강1, 정상영2, 강길선1, 김문석2, 이해방2, 조선행2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | self-microemulsifying drug delivery system; nanopartcle; dexibuprofen |
