| 초록 |
Vesicular structures can be generated from various materials such as phospholipids or surfactants for the drug delivery. It is known that amphiphilic block copolymers also form polymer vesicles, or polymersomes in aqueous solution. Usually, these structures have been generated by the conventional methods such as film rehydration or electroformation, which,however, have led to the difficulty of controlling the size. Compared to those methods, microfluidics has several advantages that allow experimental control and optimum performance which are required for reproducible self assembly of mPEG-b-PDLLA copolymers into polymersomes. In this work, we used a microchannel with a cross junction which caused hydrodynamical focusing at interfaces of pressure-driven laminar flows. These flows consisted of DI water as an aqueous phase and N,N-Dimethylformamide containing diblock copolymers as an organic one. We demonstrated the effect of flow rate on the size of polymersomes. |
