| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 가을 (11/02 ~ 11/03, 한경대학교) |
| 권호 |
11권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
5-Hydroxy-7-methoxyphthalide from the methanol extract of Sparassis crispa suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW264.7 macrophages stimulated with lipopolysaccharide |
| 초록 |
Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important enzymes that mediate inflammatory processes. Here, we investigated whether 5-hydroxy-7-methoxyphthalide (HMP) isolated from the methanol extract of Sparassis crispa, an edible mushroom, could modulate iNOS and COX-2 expression in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS).Our results suggest that HMP can inhibit NO and PGE2 productions through suppression of LPS-induced iNOS and COX-2 expression. |
| 저자 |
하영애, 이영행, 채규윤, 곽경철
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| 소속 |
원광대 |
| 키워드 |
Sparassis crispa; 5-Hydroxy-7-methoxyphthalide; Inducible nitric oxide synthase; Cyclooxygenase-2
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| E-Mail |
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