| 초록 |
In recent years, reactive oxygen species(ROS)-mediated cancer treatment, referred to as sonodynamic therapy(SDT), has emerged as a potential alternative because of its minimal invasiveness and improved site-specific action. Ultrasound can penetrate much deeper in biological tissue because it is non-radiative and has a low tissue attenuation coefficient. The ability of ultrasound to activate some sensitizer such as 5-aminolevulinic acid or TiO2 nanoparticle has led researchers to consider sonodynamic therapy as a possible alternative to photodynamic therapy(PDT). Herein, we designed a ROS stimuli-responsive self-assembled nanoparticle that can be activated by ultrasound to generate ROS. This system has potential of combination of SDT and chemotherapy for cancer treatment. |
