| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Surface modified Ceria–Zirconia Nanoparticles for Targeting Spinal Microglia and Enhanced Analgesic Treatment of Neuropathic Pain |
| 초록 |
Neuropathic pain is a chronic and pathological pain caused by injury or dysfunction in the nervous system. Pro-inflammatory microglial activation with aberrant reactive oxygen species (ROS) generation in the spinal cord plays a critical role in the development of neuropathic pain. Here, an effective strategy to treat the pain hypersensitivity using microglia-targeting ceria–zirconia nanoparticles (CZ NPs) is reported. The CZ NPs are coated with microglia-specific antibodies to promote their delivery to microglia, and thus to improve their therapeutic efficacy. The targeted delivery facilitates the elimination of both pro-inflammatory cytokines and ROS in microglia, enabling the rapid and effective inhibition of the microglial activation. As a result, greatly ameliorated mechanical allodynia is achieved in a spinal nerve transection (SNT)-induced neuropathic pain mouse model, proving the potent analgesic effect of the microglia-targeting CZ NPs. |
| 저자 |
최부민, 소민, Yelina Manadhar, 현택환, 이성중
|
| 소속 |
Seoul National Univ. |
| 키워드 |
Ceria; Nanoparticle; Microglia; Neuropathic pain
|
| E-Mail |
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