| 초록 |
A thermosensitive liposome has been applied for targeted delivery of an anticancer drug by combination with external stimuli. In particular, therapeutic approaches with high-intensity focused ultrasound (HIFU) has emerged as a promising alternative as its characteristics including hyperthermia and vasodilation, which is allowing burst release and an increase of drug accumulation in the tumor. However, hyperthermia-mediated damage on the tumor vessel decreases the efficacy of follow-up treatments due to a vascular shutdown. Therefore, we design the non-thermal HIFU therapy to improve the accumulation of liposomal drugs to tumors through the vasodilation, without vascular damage occurs. Liposomal doxorubicin containing elastin-like peptide is used for comparison of conventional hyperthermia HIFU therapy, and Cy5.5 is added to tracking theirs in vivo fate. Results show that our strategy leads to higher tissue accumulation without vessel damage than conventional hyperthermia HIFU therapy. |
