| 초록 |
The purpose of this study is application to drug delivery system for enhancement of osseointegration using UV curable natural polymer derivatives; Azido Gelatin (Az-Gel), Azido Carrageenan (Az-Car), and Azido Low-Molecular-Weight-O-Carboxymethyl Chitosan (Az-LM-O-CMC). Recently, micro-particles using natural polymers were expected to be widely used in the fields of drug delivery system. In drug delivery system, to stabilize the delivery and activity of protein is significant. Bone morphogenetic protein-2 (BMP-2) as an accelerator of osteoblastic differentiation is easy to be deactivated by enzyme and other physical / chemical conditions. In order to solve these problems, photo-immobilization methods have been studied. Azido groups are related to crosslinking reaction as they form a nitrene intermediate by UV irradiation. |
